Curcumin intake affects miRNA signature in murine melanoma with mmu-miR-205-5p most significantly altered.

ABSTRACT: Melanoma is the most aggressive form of skin cancer with estimated 48,000 deaths worldwide. The polyphenol curcumin derived from the plant Curcuma longa is well known for its anti-inflammatory and anti-cancerogenic properties. Accordingly, dietary intake of this compound may be suitable for melanoma prevention. However, how this compound affects basic cellular mechanisms in developing melanoma still remains elusive. Therefore, the aim of this study was to investigate for the first time the impact of oral curcumin administration on the miRNA signature of engrafting melanoma. For this purpose, the effects of a 4% curcumin diet on murine B78H1 melanoma were tested in a flank model. Curcumin diet or standard chow (control) was administered two weeks prior to tumor initiation until termination

ORGANISM(S): Mus musculus

SUBMITTER: Christina Backes 

PROVIDER: E-GEOD-47211 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress