Transcription profiling of E. coli arginine regulon using wild type and argR- strains grown on medium with and without arginine

ABSTRACT: Analysis of the response to arginine of the Escherichia coli K-12 transcriptome by microarray hybridization and real-time quantitative PCR provides a first coherent quantitative picture of the ArgR-mediated repression of arginine biosynthesis and uptake genes. Transcriptional repression was shown to be the major control mechanism of the biosynthetic genes, leaving only limited room for additional transcriptional or post-transcriptional regulations. The art genes coding for the specific arginine uptake system are subject to ArgR-mediated repression, ; with a strong repression of artJ, coding for the periplasmic binding protein of the system. The hisJQMP genes of the histidine transporter (part of the LAO uptake system) were discovered to be a part of the arginine regulon. Analysis of their

ORGANISM(S): Escherichia coli

SUBMITTER: Paul Van Hummelen 

PROVIDER: E-GEOD-4724 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress