The kidney collecting duct acid-base regulon

ABSTRACT: Kidneys are essential for acid-base homeostasis, especially when organisms cope with changes in acid or base dietary intake. Because collecting ducts constitute the final site for regulating urine acid-base balance, we undertook to identify the gene network involved in acid-base transport and regulation in the mouse outer medullary collecting duct (OMCD). For this purpose, we combined kidney functional studies and quantitative analysis of gene expression in OMCDs, by transcriptome and candidate gene approaches, during metabolic acidosis. Furthermore, to better delineate the set of genes concerned with acid-base disturbance, the OMCD transcriptome of acidotic mice was both compared to that of normal mice and mice undergoing an adaptative response through potassium depletion. Metabolic acido

ORGANISM(S): Mus musculus

SUBMITTER: Alain Doucet 

PROVIDER: E-GEOD-4729 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress