Zinc finger transcription factors displaced SREBP proteins as the major sterol regulators during Saccharomycotina evolution

ABSTRACT: All but a few eukaryotes die without oxygen and respond dynamically to changes in the level of oxygen available to them. One ancient oxygen-requiring biochemical pathway in eukaryotes is the pathway for the biosynthesis of sterols, leading to cholesterol in animals and ergosterol in fungi. Mutations in this pathway are a frequent cause of azole drug resistance in pathogenic fungi. The regulatory mechanism for the sterol pathway is also widely conserved between animals and fungi and is centred on a transcription activator, SREBP, that forms part of a sterol-sensing complex. However, in one group of yeasts M-bM-^@M-^S the Saccharomycotina, which includes the major pathogen Candida albicans M-bM-^@M-^S control of the sterol pathway has been taken over by an unrelated regulatory protein, Upc2.

ORGANISM(S): Yarrowia lipolytica

SUBMITTER: Geraldine Butler 

PROVIDER: E-GEOD-47433 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress