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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Recurrent 11q aberrations in MYC-neg mature aggressive B-cell lymphomas resembling BL

ABSTRACT: Copy number analysis using Agilent 244k or 180k (Case9) arrays was performed for 8 MYC-negative B-cell lymphomas, with sex-matched control DNAs Agilent 244k (cases 4-7 and 10-12) and 180k (Case9) arrays

ORGANISM(S): Homo sapiens

SUBMITTER: Itziar Salaverria

PROVIDER: E-GEOD-47506 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma.

Salaverria Itziar I Martin-Guerrero Idoia I Wagener Rabea R Kreuz Markus M Kohler Christian W CW Richter Julia J Pienkowska-Grela Barbara B Adam Patrick P Burkhardt Birgit B Claviez Alexander A Damm-Welk Christine C Drexler Hans G HG Hummel Michael M Jaffe Elaine S ES Küppers Ralf R Lefebvre Christine C Lisfeld Jasmin J Löffler Markus M Macleod Roderick A F RA Nagel Inga I Oschlies Ilske I Rosolowski Maciej M Russell Robert B RB Russell Robert B RB Rymkiewicz Grzegorz G Schindler Detlev D Schlesner Matthias M Scholtysik René R Schwaenen Carsten C Spang Rainer R Szczepanowski Monika M Trümper Lorenz L Vater Inga I Wessendorf Swen S Klapper Wolfram W Siebert Reiner R

Blood 20140107 8

The genetic hallmark of Burkitt lymphoma (BL) is the t(8;14)(q24;q32) and its variants leading to activation of the MYC oncogene. It is a matter of debate whether true BL without MYC translocation exists. Here, we identified 59 lymphomas concordantly called BL by 2 gene expression classifiers among 753 B-cell lymphomas. Only 2 (3%) of these 59 molecular BL lacked a MYC translocation, which both shared a peculiar pattern of chromosome 11q aberration characterized by interstitial gains including 1 ...[more]

PMID: 24398325

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Recurrent 11q aberrations in MYC-neg mature aggressive B-cell lymphomas resembling BL

Project description:Copy number analysis using Agilent 244k or 180k (Case9) arrays was performed for 8 MYC-negative B-cell lymphomas, with sex-matched control DNAs

2014-01-10 | GSE47506 | GEO

A recurrent 11q aberration pattern characterizes a subset of MYC-negative mature aggressive B-cell lymphomas resembling Burkitt lymphoma

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-01-10 | E-GEOD-47508 | biostudies-arrayexpress

Follicular lymphoma in situ and partial involvement by follicular lymphoma are clona lesions that carry the t(14;18) and lack genetic secondary alterations

Project description:Follicular lymphoma (FL) is characterized by the t(14;18)(q32;q21), frequent numerical chromosomal alterations, and recurrent somatic mutations. However, no genetic studies are available for FL in situ (FLIS), a putative precursor lesion of FL. In this study, we analyzed cases of FLIS without manifest (m)FL, partial involvement by FL (PFL), and paired cases of FLIS and mFL to detect possible early chromosomal imbalances, as well as DNA-methylation patterns of genomic regions of selected genes. We demonstrated that paired FLIS and mFL cases are always clonally related. FLIS and PFL have no or few secondary chromosomal imbalances detectable by copy number arrays and a lower level of gene methylation as compared to mFL. Additionally, EZH2 Tyr641 mutations were detected in a subset of both FLIS and PFL cases. In conclusion, this study provides evidence that FLIS represents a FL precursor lesion of long-lived clonal B-cells carrying the t(14;18) with no or few secondary genetic changes. The earliest secondary genetic alterations detected in FLIS are the EZH2 Tyr641 mutation and low levels of CNAs, as evidence of clonal evolution. Our data suggest that there may be more than one distinct lesion driving the progression from FLIS to manifest lymphoma. DNA from cases, 20 tumor samples (10 in situ Follicular lymphoma, 4 Partial infiltration folliculary lymphoma and 6 manifest FL) were analyzed with Agilent-014693 Human Genome CGH Microarray 244A platform for copy number alterations study. For cases 9-14 paired samples of in situ follicular lymphoma and manifest follicular lymphoma were analyzed. Agilent-014693 Human Genome CGH Microarray 244A arrays were performed according to the manufacturer's directions on DNA extracted from lymph nodes that were hybridized against a normal DNA (pool) of the same gender.

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2012-12-19 | E-GEOD-42917 | biostudies-arrayexpress

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Deletion of UTX, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome.

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