Transcription profiling of rats subjected to hypoxic preconditioning or sham conditioning at several time points from 0 to 24 hrs after preconditioning

ABSTRACT: Hypoxic-ischemic (HI) injury in the developing brain is a common cause of disability in children, and there are no effective treatments at this time. Exposure to sublethal hypoxic conditions (hypoxic preconditioning) 24 hours prior to hypoxic-ischemic insult is protective in the developing rat model. We have observed protective effects on brain histopathology and on long-term sensory-motor behavioral tasks. Changes in gene expression are thought to underlie this protective effect. By comparing gene expression in rats subjected to hypoxic preconditioning or sham conditioning at several time points from 0 to 24 hrs after preconditioning, we should gain insight into the mechanisms underlying these neuroprotective effects and may identify targets for therapeutic intervention. The aim of th

ORGANISM(S): Rattus norvegicus

SUBMITTER: Elizabeth Salomon 

PROVIDER: E-GEOD-4753 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress