Transcription profiling of human neurons with and without neurofibriallary tangles from Alzheimer's patients

ABSTRACT: Alzheimer's Disease (AD) is a devastating neurodegenerative disorder affecting approximately 4 million people in the U.S. alone. AD is characterized by the presence of senile plaques and neurofibrillary tangles in cortical regions of the brain. These pathological markers are thought to be responsible for the massive cortical neurodegeneration and concomitant loss of memory, reasoning, and often aberrant behaviors that are seen in patients with AD. Understanding the molecular mechanisms whereby these histopathological markers develop will greatly enhance our understanding of AD development and progression. A clearer understanding of the mechanisms underlying neurofibrillary tangle formation specifically may help to clarify the basis for dementia of AD as well as the dementias associated

ORGANISM(S): Homo sapiens

SUBMITTER: Elizabeth Salomon 

PROVIDER: E-GEOD-4757 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress