Gene expression profiling in whole blood in patients for KlinefelterM-bM-^@M-^Ys Syndrome

ABSTRACT: To study the difference of gene expression pattern of whole blood between klinefelterM-bM-^@M-^Ys syndrome and normal individuals and discovered the disease-related genes and biological pathway. 717 differentially expressed genes (480 up regulated, 237 down regulated) were identified between whole blood samples of the klinefelterM-bM-^@M-^Ys patients and normal volunteers. Function enrichment analysis identified a number of genes involved in immune response, metabolism etc. Three genes with significant down-regulation in KlinefelterM-bM-^@M-^Ys patients were also confirmed by qRT-PCR.Using the whole blood as material in patients with klinefelterM-bM-^@M-^Ys syndrome, the differentially expressed genes was identified. It is noticed that genes involved in metabolism pathways were significant

ORGANISM(S): Homo sapiens

SUBMITTER: wang liang 

PROVIDER: E-GEOD-47584 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress