Novel insights into DNA methylation features in spermatozoa: stability and peculiatities

ABSTRACT: Data about the entire sperm DNA methylome are limited to two sperm donors whereas studies dealing with a greater number of subjects focused only on a few genes or were based on low resolution arrays. This implies that information about what we can consider as a normal sperm DNA methylome and whether it is stable among different normozoospermic individuals is still missing. The definition of the DNA methylation profile of normozoospermic men, the entity of inter-individual variability and the epigenetic characterization of quality-fractioned sperm subpopulations in the same subject (intra-individual variability) are relevant for a better understanding of pathological conditions. We addressed these questions by using the high resolution Infinium 450K methylation array and compared normal spe

ORGANISM(S): Homo sapiens

SUBMITTER: Antonio Gómez 

PROVIDER: E-GEOD-47627 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress