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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Global peripheral blood gene expression study and trans-eQTLs [HumanHT-12 V4.0]

ABSTRACT: The objective of this analysis was to identify trans-eQTLs. Samples were collected from control participants of the Heart and Vascular Health (HVH) study that constitutes a group of population based case control studies of myocardial infarction (MI), stroke, venous thromboembolism (VTE), and atrial fibrillation (AF) conducted among 30-79 year old members of Group Health, a large integrated health care organization in Washington State. Total RNA was isolated from peripheral collected using PAXgene tubes and gene expression was profiled using the Illumina platform.

ORGANISM(S): Homo sapiens

SUBMITTER: Daniel Enquobahrie

PROVIDER: E-GEOD-47728 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Global peripheral blood gene expression study and trans-eQTLs [HumanHT-12 V3.0]

Project description:The objective of this analysis was to identify trans-eQTLs. Samples were collected from control participants of the Heart and Vascular Health (HVH) study that constitutes a group of population based case control studies of myocardial infarction (MI), stroke, venous thromboembolism (VTE), and atrial fibrillation (AF) conducted among 30-79 year old members of Group Health, a large integrated health care organization in Washington State. Total RNA was isolated from peripheral collected using PAXgene tubes and gene expression was profiled using the Illumina platform.

2013-06-08 | E-GEOD-47727 | biostudies-arrayexpress

Global peripheral blood gene expression study and trans-eQTLs

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-06-08 | E-GEOD-47729 | biostudies-arrayexpress

Global peripheral blood gene expression study [HumanHT-12 V4.0]

Project description:Samples were collected from 'control participants' of the Heart and Vascular Health (HVH) study that constitutes a group of population based case control studies of myocardial infarction (MI), stroke, venous thromboembolism (VTE), and atrial fibrillation (AF) conducted among 30-79 year old members of Group Health, a large integrated health care organization in Washington State.

2013-06-08 | GSE47728 | GEO

Global peripheral blood gene expression study [HumanHT-12 V3.0]

2013-06-08 | GSE47727 | GEO

Whole Blood Gene Expression Profiles Distinguish Patients with Single versus Recurrent Venous Thromboembolism

Project description:Venous thromboembolism (VTE) is a major cause of morbidity and mortality. Pulmonary embolism is a life threatening manifestation of VTE that occurs in at least half the patients on presentation. In addition, VTE recurs in up to 30% of patients after a standard course of anticoagulation, and there is not a reliable way of predicting recurrence. We investigated whether gene expression profiles of whole blood could distinguish patients with VTE from healthy controls, single VTE from those with recurrence, and DVT alone from those with PE. 70 adults with VTE on warfarin and 63 healthy controls were studied. Patients with antiphospholipid syndrome or cancer were excluded. Blood was collected in PAXgene tubes, RNA isolated, and gene expression profiles obtained using Affymetrix arrays. We developed a 50 gene model that distinguished healthy controls from subjects with VTE with excellent receiver operating characteristics (AUC 0.94; P < 0.0001). We also discovered a separate 50 gene model that distinguished subjects with a single VTE from those with recurrent VTE with good receiver operating characteristics (AUC 0.75; P=0.008). In contrast, we were unable to distinguish subjects with DVT from those with PE using gene expression profiles. Gene expression profiles of whole blood can distinguish subjects with VTE from healthy controls and subjects with a single VTE from those with recurrence. Additional studies should be performed to validate these results and develop diagnostic tests. Gene expression profiling is likely translatable to other thrombotic disorders(e.g., patients with cancer and VTE).

2011-11-10 | GSE19151 | GEO

Homo sapiens

Project description:NHLBI TOPMed: Mayo Clinic Venous Thromboembolism (VTE) Study

| PRJNA393377 | ENA

NHLBI TOPMed: Mayo Clinic Venous Thromboembolism (VTE) Study

Project description:NHLBI TOPMed: Mayo Clinic Venous Thromboembolism (VTE) Study

| PRJNA393376 | ENA

Whole Blood Gene Expression Profiles Distinguish Patients with Single versus Recurrent Venous Thromboembolism

2011-11-10 | E-GEOD-19151 | biostudies-arrayexpress

An evolutionary conserved, immobility associated antithrombotic mechanism

Project description:Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a main cause of morbidity and mortality that causes tremendous health care costs. Short term immobility related conditions arising from hospitalization, acute trauma and forced bed rest are major risk factors for the development of VTE. In contrast, chronically paralyzed patients with post-spinal cord injury are protected from VTE despite immobilization. Similarly, free-ranging brown bears (Ursus arctos) that hibernate (immobilize) have adapted to this threat through yet to be discovered mechanisms and do not develop VTE. This suggests that long-term immobility can induce antithrombotic mechanisms that are evolutionarily conserved. Here we aimed to identify these adaptive mechanisms of VTE protection in a cross-species approach. Mass spectrometry-based proteomics identified platelet expressed heat shock protein 47 (Hsp47) as the most substantially downregulated protein during brown bear hibernation. In a clinical bed rest study and in spinal-cord injured humans, we likewise observed drastic reduction of platelet-expressed Hsp47. Genetic ablation and pharmaceutical inhibition of platelet Hsp47 attenuates deep vein thrombosis and thromboinflammatory responses in mice and human blood cells. This suggests that Hsp47 downregulation is an evolutionarily conserved mechanism that also protects immobilized patients from VTE. Our translational approach thus identified an antithrombotic signature that may give rise to novel antithrombotic therapeutics and prognostic markers.

2023-04-14 | PXD031521 | Pride

An evolutionary conserved, immobility associated antithrombotic mechanism

2023-04-14 | PXD039087 | Pride

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