Interplay of host microbiota, genetic perturbations, and inflammation promote local development of intestinal neoplasms in mice

ABSTRACT: The preferential localization of some neoplasms, such as serrated polyps, in specific areas of the intestine suggests that non-genetic factors may be important for their development. To test this hypothesis, we took advantage of transgenic mice that expressed HB-EGF throughout the intestine, but develop serrated polyps only in the cecum. Here we show that a host-specific microbiome was associated with serrated polyps, and that alterations of the microbiota induced by antibiotic treatment or by embryo-transfer rederivation markedly inhibited the formation of serrated polyps in the cecum. Mechanistically, development of serrated polyps was associated with a local decrease in epithelial barrier-function, bacterial invasion, production of antimicrobials, and increased expression of several inf

ORGANISM(S): Mus musculus

SUBMITTER: Gerold Bongers 

PROVIDER: E-GEOD-47735 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress