Transcriptional profiling of dentate granule cells in 4 rat epilepsy models

ABSTRACT: Global expression profiling of epileptogenesis has been confounded by variability across laboratories, epilepsy models, tissue sampled and experimental platforms, with the result that very few genes demonstrate consistent expression changes. The present study minimizes these confounds by combining Affymetrix microarray datasets from seven laboratories, using three status epilepticus (SE) models of epilepsy in rats (pilocarpine, kainate, self-sustained SE or SSSE) and the rat kindling model. Total RNA was harvested from laser-captured dentate granule cells from 6 rats at three times during the early-to-mid latent phase that precedes epilepsy symptoms in the SE models (1, 3 and 10 days after SE), or 24 hr after the first stage 2, stage 4 and stage 5 seizure in the kindling model. Each epile

ORGANISM(S): Rattus norvegicus

SUBMITTER: Winnie Liang 

PROVIDER: E-GEOD-47752 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress