Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Tumor-educated circulating monocytes are powerful specific biomarkers for diagnosis of colorectal cancer

ABSTRACT: Analysis of tumor-educated changes in peripheral blood monocytes at the gene expression level. We analyzed if gene expression in monocytes of patients with colorectal cancer is differential from those of healthy volunteers and found a diagnostic signature that allowed to accurately discriminate patients with colorectal cancer from healthy individuals. Peripheral blood monocytes from 93 distinct individuals are profiled on 8 beadchips. The individuals belong to one of three groups: healthy volunteers (38), patients with non-metastatic colorectal cancer (27) or patients with metastatic colorectal cancer (28).

ORGANISM(S): Homo sapiens

SUBMITTER: Wouter Van Delm

PROVIDER: E-GEOD-47756 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Tumour-educated circulating monocytes are powerful candidate biomarkers for diagnosis and disease follow-up of colorectal cancer.

Hamm Alexander A Prenen Hans H Van Delm Wouter W Di Matteo Mario M Wenes Mathias M Delamarre Estelle E Schmidt Thomas T Weitz Jürgen J Sarmiento Roberta R Dezi Angelo A Gasparini Giampietro G Rothé Françoise F Schmitz Robin R D'Hoore André A Iserentant Hannes H Hendlisz Alain A Mazzone Massimiliano M

Gut 20150326 6

<h4>Objective</h4>Cancer immunology is a growing field of research whose aim is to develop innovative therapies and diagnostic tests. Starting from the hypothesis that immune cells promptly respond to harmful stimuli, we used peripheral blood monocytes in order to characterise a distinct gene expression profile and to evaluate its potential as a candidate diagnostic biomarker in patients with colorectal cancer (CRC), a still unmet clinical need.<h4>Design</h4>We performed a case-control study in ...[more]

PMID: 25814648

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Project description:This a model from the article: An integrated model for glucose and insulin regulation in healthy volunteers and type 2 diabetic patients following intravenous glucose provocations. Silber HE, Jauslin PM, Frey N, Gieschke R, Simonsson US, Karlsson MO. J Clin Pharmacol. 2007 Sep;47(9):1159-71. 17766701 , Abstract: An integrated model for the regulation of glucose and insulin concentrations following intravenous glucose provocations in healthy volunteers and type 2 diabetic patients was developed. Data from 72 individuals were included. Total glucose, labeled glucose, and insulin concentrations were determined. Simultaneous analysis of all data by nonlinear mixed effect modeling was performed in NONMEM. Integrated models for glucose, labeled glucose, and insulin were developed. Control mechanisms for regulation of glucose production, insulin secretion, and glucose uptake were incorporated. Physiologically relevant differences between healthy volunteers and patients were identified in the regulation of glucose production, elimination rate of glucose, and secretion of insulin. The model was able to describe the insulin and glucose profiles well and also showed a good ability to simulate data. The features of the present model are likely to be of interest for analysis of data collected in antidiabetic drug development and for optimization of study design. This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Dataset Information

Tumor-educated circulating monocytes are powerful specific biomarkers for diagnosis of colorectal cancer

Publications

Tumour-educated circulating monocytes are powerful candidate biomarkers for diagnosis and disease follow-up of colorectal cancer.

Similar Datasets

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