STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and BarrettM-bM-^@M-^Ys adenocarcinomas

ABSTRACT: Signal transducer and activator of transcription 3 (STAT3) is altered in several epithelial cancers and represents a potential therapeutic target. Here, STAT3 expression, activity and cellular functions were examined in two main histotypes of esophageal carcinomas. In situ, immunohistochemistry for STAT3 and STAT3-Tyr705 phosphorylation (P-STAT3) in esophageal squamous cell carcinomas (ESCC) and BarrettM-bM-^@M-^Ys adenocarcinomas (BAC) revealed similar STAT3 expression in ESCCs and BACs, but preferentially activated P-STAT3 in ESCCs. In vitro, strong STAT3 activation was seen by EGF-stimulation in OE21 (ESCC) cells, whilst OE33 (BAC) cells showed constitutive weak STAT3 activation. STAT3 knockdown significantly reduced cell proliferation of OE21 and OE33 cells and reduced cell migration i

ORGANISM(S): Homo sapiens

SUBMITTER: Hauke Busch 

PROVIDER: E-GEOD-47763 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress