LncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: MICHAEL ROSENFELD
PROVIDER: E-GEOD-47807 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs.
Yang Liuqing L Lin Chunru C Jin Chunyu C Yang Joy C JC Tanasa Bogdan B Li Wenbo W Merkurjev Daria D Ohgi Kenneth A KA Meng Da D Zhang Jie J Evans Christopher P CP Rosenfeld Michael G MG
Nature 20130814 7464
Although recent studies have indicated roles of long non-coding RNAs (lncRNAs) in physiological aspects of cell-type determination and tissue homeostasis, their potential involvement in regulated gene transcription programs remains rather poorly understood. The androgen receptor regulates a large repertoire of genes central to the identity and behaviour of prostate cancer cells, and functions in a ligand-independent fashion in many prostate cancers when they become hormone refractory after initi ...[more]
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