PML regulates NF-κB phosphorylation and transcriptional activity

ABSTRACT: The transcription factor NF-κB is considered the master regulator of the immune response but also acts broadly to regulate gene expression that influences cell survival, proliferation and differentiation. Post-translational modification of NF-κB, phosphorylation in particular, is essential for the transactivation activity of NF-κB. Emerging evidence suggests that the regulation of NF-κB in the nucleus is critical in controlling gene expression. Promyelocytic Leukemia (PML) is a nuclear protein that forms nuclear bodies (PML NBs), sub-nuclear structures that are associated with transcriptionally active genomic regions that have been implicated in multiple processes such as apoptosis, senescence and anti-viral responses. Chromosomal translocations leading to the expression of a PML-retin

ORGANISM(S): Mus musculus

SUBMITTER: Ruaidhri Carmody 

PROVIDER: E-GEOD-47828 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress