Crosstalk between the effects of extracellular vesicles (Evs) and TNF on U937 human monocyte cell line
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Katalin Szabo-Taylor
PROVIDER: E-GEOD-47897 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Critical role of extracellular vesicles in modulating the cellular effects of cytokines.
Szabó Géza Tamás GT Tarr Bettina B Pálóczi Krisztina K Éder Katalin K Lajkó Eszter E Kittel Ágnes Á Tóth Sára S György Bence B Pásztói Mária M Németh Andrea A Osteikoetxea Xabier X Pállinger Éva É Falus András A Szabó-Taylor Katalin K Buzás Edit Irén EI
Cellular and molecular life sciences : CMLS 20140406 20
Under physiological and pathological conditions, extracellular vesicles (EVs) are present in the extracellular compartment simultaneously with soluble mediators. We hypothesized that cytokine effects may be modulated by EVs, the recently recognized conveyors of intercellular messages. In order to test this hypothesis, human monocyte cells were incubated with CCRF acute lymphoblastic leukemia cell line-derived EVs with or without the addition of recombinant human TNF, and global gene expression c ...[more]
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