Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I

ABSTRACT: Segregation of homologous maternal and paternal centromeres to opposite poles during meiosis I depends on post-replicative crossing over between homologous non-sister chromatids, which creates chiasmata and therefore bivalent chromosomes. Destruction of sister chromatid cohesion along chromosome arms due to proteolytic cleavage of cohesin's Rec8 subunit by separase resolves chiasmata and thereby triggers the first meiotic division. This produces univalent chromosomes, the chromatids of which are held together by centromeric cohesin that has been protected from separase by shugoshin (Sgo1/MEI-S332) proteins. Here we show in both fission and budding yeast that Sgo1 recruits to centromeres a specific form of protein phosphatase 2A (PP2A). Its inactivation causes loss of centromeric cohesin at

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Kim Nasmyth 

PROVIDER: E-GEOD-4791 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress