Identification of genetic variants that affect histone modifications in human cells

ABSTRACT: Histone modifications are important markers of function and chromatin state, yet the DNA elements that direct them to specific locations in the genome are poorly understood. Here we use the genetic variation in Yoruba lymphoblastoid cell lines as a natural experiment to identify genetic differences that affect histone marks and to better understand their relationship with transcriptional regulation. Across the genome, we identified hundreds of quantitative trait loci that impact histone modification or RNA polymerase (PolII) occupancy. In many cases the same variant is associated with quantitative changes in multiple histone marks and PolII, as well as in DNaseI sensitivity and nucleosome positioning, indicating that these molecular phenotypes often share a single underlying genetic cause.

ORGANISM(S): Homo sapiens

SUBMITTER: Graham McVicker 

PROVIDER: E-GEOD-47991 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress