Host directed activity of Pyrazinamide in Mycobacterium tuberculosis infection

ABSTRACT: Pyrazinamide (PZA) is one of the first line antibiotics used for the treatment of tuberculosis (TB). we have used human monocyte and a mouse model of pulmonary TB to investigate whether treatment with PZA, in addition to its known anti-mycobacterial properties, modulate the host immune response during Mycobacterium tuberculosis (Mtb) infection. Mice were infected with Mtb and treatment with PZA was started at 28 days post-infection. At 42 days and 63 days post-infection, group of animals were euthanized and lung tissue was collected to isolate total RNA and used in microarray experiments. Mtb-infected, untreated animals served as controls.

ORGANISM(S): Mus musculus

SUBMITTER: Selvakumar Subbian 

PROVIDER: E-GEOD-48027 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress