Molecular Basis of Renal Adaptation in a Murine Model of Congenital Obstructive Nephropathy

ABSTRACT: Congenital obstructive nephropathy is a common cause of chronic kidney disease and a leading indication for renal transplant in children. The cellular and molecular responses of the kidney to congenital obstruction are incompletely characterized. In this study, we evaluated global transcription in kidneys with graded hydronephrosis in the megabladder (mgb-/-) mouse to better understand the pathophysiology of congenital obstructive nephropathy. Three primary pathways associated with kidney remodeling/repair were induced in mgb-/- kidneys independent of the degree of hydronephrosis. These pathways included retinoid signaling, steroid hormone metabolism, and renal response to injury. Urothelial proliferation and the expression of genes with roles in the integrity and maintenance of the renal

ORGANISM(S): Mus musculus

SUBMITTER: Ashley Carpenter 

PROVIDER: E-GEOD-48041 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress