Expression signature as a biomarker for prenatal diagnosis of trisomy 21

ABSTRACT: To date, a universal biomarker panel with a potential to predict high-risk pregnancies or adverse pregnancy outcome does not exist. Transcriptomic approach, a measure of gene expression levels across the genome, is a powerful tool to capture differentially expressed genes (DEG) in various conditions, including human trisomy of chromosome 21 (Ts21). DEG can be used to design a biomarker set as a diagnostic-predictive tool for various conditions of heterogeneous aetiology in a prenatal setting. In the search of novel biomarker set to predict high-risk pregnancies, we performed global expression profiling to find DEG in Ts21 used as a model. Subsequently we performed targeted validation and diagnostic performance evaluation on a larger group of case and control samples. Initially, transcript

ORGANISM(S): Homo sapiens

SUBMITTER: Ales Maver 

PROVIDER: E-GEOD-48051 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress