Developmental exposure to valproic acid alters the expression of microRNAs involved in neurodevelopment in zebrafish

ABSTRACT: Congenital malformations are a prevalent cause of infant mortality in the United States and their induction has been linked to a variety of factors, including exposure to teratogens. However, the molecular mechanisms of teratogenicity are not fully understood. MicroRNAs are an important group of small, non-coding RNAs that regulate mRNA expression. MicroRNA roles in early embryonic development are well established, and their disruption during development can cause abnormalities. We hypothesized that developmental exposure to teratogens such as valproic acid alters microRNA expression profiles in developing embryos. Valproic acid is an anticonvulsant and mood-stabilizing drug used to treat epilepsy, bipolar disorder and migraines. To examine the effects of valproic acid on microRNA expressi

ORGANISM(S): Danio rerio

SUBMITTER: Neelakanteswar Aluru 

PROVIDER: E-GEOD-48054 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress