Transcription profiling of human T-lymphocytes from the adaptive immune system from smojers and non smokers

ABSTRACT: Cigarette smoke components have a proven negative influence on human health. Adverse metabolic effects have been observed in tissues and single cells. As T-lymphocytes get in contact with affected organs (e.g. lung) or cells (e.g.erythrocytes), as well as with smoke components and bioactive molecules, whose production is influenced by them, we compared the gene exression profiles in these cells of the adaptive immune system of three male heavy smokers and three male non-smokers We combined rapid immuno-precipitation and Affymetrix GeneChip® HG U133A2.0 microarray analysis to analyse the data set. 88 genes were found significantly (T-test) differentially expressed by a factor of 1.5-fold or larger between smokers and non-smokers. Using the gene function groups of the gene ontology consorti

ORGANISM(S): Homo sapiens

SUBMITTER: Sandy Mosig 

PROVIDER: E-GEOD-4806 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress