Crosstalk between the STAT3, NF-kB and Notch signaling pathways in glioblastoma stem cells

ABSTRACT: In this study, we describe a novel relationship between glioblastoma CSCs and the Notch pathway, which involves the constitutive activation of STAT3 and NF-κB signaling. We demonstrate that adherent glioma CSCs exhibit characteristics previously described for CSCs grown in suspension culture. The expression of CD133, Sox2 and Nestin increased when compared to glioma cells grown in monolayer, and the adherent CSCs were ~100 times more tumorigenic in vivo than monolayer cultured glioma cells. We also found that while the STAT3 and NF-κB signaling pathways are constitutively activated in glioma lines, these pathways are dramatically activated in glioma CSCs. Treatment with STAT3 inhibitors led to a loss of nuclear activation of STAT3 signaling and suppression of growth in both monolayer and C

ORGANISM(S): Homo sapiens

SUBMITTER: Jo Garner 

PROVIDER: E-GEOD-48079 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress