Characterization of osteogenic differentiation and gene expression profile of multiple miliary osteoma cutis

ABSTRACT: Multiple miliary osteoma cutis (MMOC) is a rare skin disorder characterized by heterotopic ossification in dermis and subcutis. The etiology and disease mechanism is unknown, but earlier data indicates that it seems to be different from other diseases containing heterotopic intramembranous ossification. The purpose of this study was to further investigate the pathogenesis of MMOC by comparing patients’ osteoma affected skin area to their unaffected healthy skin area, as well as to skin from controls. This comparison was made by using osteogenic differentiation studies in cell cultures and by gene expression experiments. Both patient and control dermal fibroblast-like cells were able to differentiate into osteoblast-like matrix mineralizing cells. The differentiation seems to diminish with

ORGANISM(S): Homo sapiens

SUBMITTER: Jussi Vuoristo 

PROVIDER: E-GEOD-48120 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress