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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Identification of miRNA targets in breast cancer cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Meiyun Fan

PROVIDER: E-GEOD-48162 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Comprehensive analysis of microRNA (miRNA) targets in breast cancer cells.

Fan Meiyun M Krutilina Raisa R Sun Jing J Sethuraman Aarti A Yang Chuan He CH Wu Zhao-Hui ZH Yue Junming J Pfeffer Lawrence M LM

The Journal of biological chemistry 20130806 38

MicroRNAs (miRNAs) regulate mRNA stability and translation through the action of the RNAi-induced silencing complex. In this study, we systematically identified endogenous miRNA target genes by using AGO2 immunoprecipitation (AGO2-IP) and microarray analyses in two breast cancer cell lines, MCF7 and MDA-MB-231, representing luminal and basal-like breast cancer, respectively. The expression levels of ∼70% of the AGO2-IP mRNAs were increased by DROSHA or DICER1 knockdown. In addition, integrated a ...[more]

PMID: 23921383

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