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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression profiling of luminal and glandular epithelia in the neonatal and adult mouse uterus

ABSTRACT: Laser capture microdissection coupled with microarray genes expression analysis were utilized in order to elucidate the regulatory networks active in epithelial cells of the neonatal and adult mouse uterus. Genes predominantly expressed in the glandular epithelium (GE) in the neonatal or adult uterus were determined by comparing transcripts in the isolated samples of luminal epithelium (LE) and GE from postnatal day (PD) 10, day of psudopregnancy (DOPP) 2.5 or DOPP 3.5 uteri (n=2/cell type/day).

ORGANISM(S): Mus musculus

SUBMITTER: Thomas Spencer

PROVIDER: E-GEOD-48239 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cell-specific transcriptional profiling reveals candidate mechanisms regulating development and function of uterine epithelia in mice.

Filant Justyna J Spencer Thomas E TE

Biology of reproduction 20131010 4

All mammalian uteri have luminal (LE) and glandular epithelia (GE) in their endometrium. The LE mediates uterine receptivity and blastocyst attachment for implantation, and the GE synthesize and secrete or transport bioactive substances involved in blastocyst implantation, uterine receptivity, and stromal cell decidualization. However, the mechanisms governing uterine epithelial development after birth and their function in the adult are not fully understood. Here, comprehensive microarray analy ...[more]

PMID: 23946541

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