Gene expression data from human NSCLC U1810 residual clones 9 days after a one-hour pulse treatment with cisplatin

ABSTRACT: Background: The platinum compounds cisplatin and carboplatin are the mainstay of chemotherapy for lung cancer; however, treatment failure remains a critical issue since about 60% of all non-small cell lung cancer (NSCLC) patients display intrinsic platinum resistance. Methods: We analyzed global gene expression profiles in NSCLC clones surviving a pulse treatment with cisplatin by microarray and mapped deregulated signaling networks in silico by Ingenuity Pathway Analysis (IPA). Results: Cisplatin-surviving NSCLC clones were demonstrated to have heterogeneous gene expression patterns both in terms of the number and the identity of the altered genes. Genes involved in Wnt signaling pathway (DKK1), DNA repair machinery (XRCC2) and cell-cell/ cell-matrix interaction (FMN1 and LGALS9) were amo

ORGANISM(S): Homo sapiens

SUBMITTER: Lovisa Lundholm 

PROVIDER: E-GEOD-48244 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress