Intragraft transcriptional profiling of renal transplant patients with tubular dysfunction after distinct immunosuppressive regimens

ABSTRACT: Intragraft transcriptional profiles were investigated in patients with tubular dysfunction to disclose subclinical mechanisms underlying graft deterioration. Moreover, we analyzed whether individualization of immunosuppression could modify this profile while improving renal function after 12 months of regimen modification. 33 renal transplant patients were enrolled in the study considering their high urinary levels of retinol binding protein, a biomarker of proximal tubular dysfunction (PTD). They were divided in two groups regarding immunosuppressive therapy. At time zero (t0), 33 patients were biopsied and 18 patients had their immunosuppression regimen modified, namely, reduction of cyclosporine dosage and introduction of mycophenolate mofetil (MYF), while 15 patients remained under az

ORGANISM(S): Homo sapiens

SUBMITTER: Hatylas Azevedo 

PROVIDER: E-GEOD-48250 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress