Dynamics of SREBP1 binding to DNA in mouse liver

ABSTRACT: To systematically understand how the circadian clock and the nutrient-driven rhythm integrate to regulate SREBP1 activity, we evaluated genome-wide the binding of SREBP1 to its targets along the day in wild-type (WT) C57BL/6mice. The recruitment of SREBP1 to the DNA showed a highly circadian behaviour, with a maximum during the fed status. However, the temporal expression of SREBP1 targets was not always synchronized with its binding. In particular, a different phase of expression was observed for SREBP1 target genes depending on their function, suggesting the involvement of other transcription factors in their regulation. The proper temporal expression pattern of these genes was dramatically changed in Bmal1KO mice upon time-restricted feeding, in spite of the rhythmic, although slightly

ORGANISM(S): Mus musculus

SUBMITTER: Beatrice Desvergne 

PROVIDER: E-GEOD-48375 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress