Concurrent Gene Signatures for Han Chinese Breast Cancers [Affymetrix]

ABSTRACT: The interplay between copy number variation (CNV) and differential gene expression may be able to shed light on molecular process underlying breast cancer and lead to the discovery of cancer-related genes. In the current study, genes concurrently identified in array comparative genomic hybridization (CGH) and gene expression microarrays were used to derive gene signatures for Han Chinese breast cancers. We performed 23 array CGHs and 81 gene expression microarrays in breast cancer samples from Taiwanese women. Genes with coherent patterns of both CNV and differential gene expression were identified from the 21 samples assayed using both platforms. We used these genes to derive signatures associated with clinical ER and HER2 status and disease-free survival. Distributions of signature g

ORGANISM(S): Homo sapiens

SUBMITTER: Chi-Cheng Huang 

PROVIDER: E-GEOD-48390 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress