Transcription profiling of human melanomas to assess metastatic potential defined by specific gene expression profiles with no BRAF signature

ABSTRACT: The molecular biology of metastatic potential in melanoma has been studied many times previously and changes in the expression of many genes have been linked to metastatic behaviour. What is lacking is a systematic characterization of the regulatory relationships between genes whose expression is related to metastatic potential. Such a characterization would produce a molecular taxonomy for melanoma which could feasibly be used to identify epigenetic mechanisms behind changes in metastatic behaviour. To achieve this we carried out three separate DNA microarray analyses on a total of 86 cultures of melanoma. Significantly, multiple testing correlation revealed that previous reports describing correlations of gene expression with activating mutations in BRAF or NRAS were incorrect and that

ORGANISM(S): Homo sapiens

SUBMITTER: Keith Hoek 

PROVIDER: E-GEOD-4840 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress