Genome-wide promoter methylation analysis of human osteoarthritis

ABSTRACT: Osteoarthritis (OA) is a chronic disease of the joint characterized by a progressive degradation of articular cartilage and subchondral bone. In healthy tissue, specialized cells called chondrocytes are regulating a balanced cartilage catabolism and anabolism. By contrast osteoarthritic joints are characterized by a dramatic increase of cartilage catabolism, due to changes of gene expression patterns within chondrocytes. To identify potential epigenetic differences regulating this process a genome-wide methylation screening of paired unaffected and osteoarthritic knee cartilage samples was performed. Therefore samples of macroscopic arthritic and non-arthritic cartilage areas of the femoral condyle of five female patients were collected and DNA isolation was performed. For being able to

ORGANISM(S): Homo sapiens

SUBMITTER: Manuela Hofner 

PROVIDER: E-GEOD-48422 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress