Sarcoptes scabiei Mites Modulate Gene Expression In Human Skin Equivalents
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Michael Markey
PROVIDER: E-GEOD-48459 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Sarcoptes scabiei mites modulate gene expression in human skin equivalents.
Morgan Marjorie S MS Arlian Larry G LG Markey Michael P MP
PloS one 20130805 8
The ectoparasitic mite, Sarcoptes scabiei that burrows in the epidermis of mammalian skin has a long co-evolution with its hosts. Phenotypic studies show that the mites have the ability to modulate cytokine secretion and expression of cell adhesion molecules in cells of the skin and other cells of the innate and adaptive immune systems that may assist the mites to survive in the skin. The purpose of this study was to identify genes in keratinocytes and fibroblasts in human skin equivalents (HSEs ...[more]
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