Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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RING1B binding in the 11 dpc embryonic tissues

ABSTRACT: We report the distribution of RING1B (one of Polycomb group factors) within the genome of mouse embryonic tissues. We prepared the chromatin from 11 dpc embryonic forebrain, midbrain, and forelimb buds and made chromatin precipitation with antibody against RING1B (mouse monoclonal antibody). High-throughput sequencing applied for the ChIP analysis revealed the differential distribution of RING1B protein among embryonic tissues. ChIP analysis of mouse 11 dpc embryonic forebrain, midbrain and forelimb buds against anti-RING1B antibody.

ORGANISM(S): Mus musculus

SUBMITTER: Takaho Endo 

PROVIDER: E-GEOD-48464 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer.

Kondo Takashi T   Isono Kyoichi K   Kondo Kaori K   Endo Takaho A TA   Itohara Shigeyoshi S   Vidal Miguel M   Koseki Haruhiko H  

Developmental cell 20131226 1

Polycomb-group (PcG) proteins mediate repression of developmental regulators in a reversible manner, contributing to their spatiotemporally regulated expression. However, it is poorly understood how PcG-repressed genes are activated by developmental cues. Here, we used the mouse Meis2 gene as a model to identify a role of a tissue-specific enhancer in removing PcG from the promoter. Meis2 repression in early development depends on binding of RING1B, an essential E3 component of PcG, to its promo  ...[more]

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