Control of RNA stability by NrrF, an iron-regulated small RNA in Neisseria gonorrhoeae.

ABSTRACT: Regulation of gene expression by small non-coding RNAs (sRNAs) plays a critical role in bacterial response to physiological stresses. NrrF, a trans-acting sRNA in Neisseria meningitidis and Neisseria gonorrhoeae, has been shown in the meningococcus to indirectly control, in response to iron (Fe) availability, the transcription of genes encoding subunits of succinate dehydrogenase, a Fe-requiring enzyme. Given that in other organisms sRNAs target multiple mRNAs to control gene expression, we used a global approach to examine the role of NrrF in controlling gonococcal transcription. Three strains, including N. gonorrhoeae FA1090, an nrrF deletion mutant and a complemented derivative were examined using a custom CombiMatrix microarray to assess the role of this sRNA in controlling gene exp

ORGANISM(S): Neisseria gonorrhoeae

SUBMITTER: Lydgia Jackson 

PROVIDER: E-GEOD-48526 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress