Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data of A224 cell with ectopic overexpression of FGF18 and RFP

ABSTRACT: We have identified the overexpression of FGF18 as an independent predictive marker for poor clinical outcome in patients with advanced stage, high-grade serous ovarian cancer. Functional studies have demonstrated that FGF18 promotes migration, invasion and tumorigenicity of ovarian cancer cells in vitro and in vivo. To identify the FGF18 responsive genes contributing its biologic effects on ovarian tumorigenesis, we performed gene expression profiling in ovarian cancer cell line A224 with ectopic overexpression of FGF18 or RFP (as control). Microarrays were completed using total genomic DNA free RNA extracted from three independent paired cultures of A224 cells overexpressing FGF18 or RFP.

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Birrer 

PROVIDER: E-GEOD-48567 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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FGF18 as a prognostic and therapeutic biomarker in ovarian cancer.

Wei Wei W   Mok Samuel C SC   Oliva Esther E   Kim Sung-hoon SH   Kim Sung-hoon SH   Mohapatra Gayatry G   Birrer Michael J MJ  

The Journal of clinical investigation 20130909 10

High-throughput genomic technologies have identified biomarkers and potential therapeutic targets for ovarian cancer. Comprehensive functional validation studies of the biological and clinical implications of these biomarkers are needed to advance them toward clinical use. Amplification of chromosomal region 5q31-5q35.3 has been used to predict poor prognosis in patients with advanced stage, high-grade serous ovarian cancer. In this study, we further dissected this large amplicon and identified  ...[more]

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