MicroRNA signature predict chemotherapy response in patients with advanced colorectal cancer

ABSTRACT: The aim of our study was to evaluate the ability of miRNA expression patterns to predict chemotherapy response in a cohort of 39 patients with metastatic colorectal carcinoma To define miRNA signature, samples were obtained from tumor tissue samples of 39 patients . Patients were divided into responders or non-responders according to tresponse treatment with a chemotherapy regimen that included fluoropyrimidines and either oxaliplatin or irinotecan .Tumor response was evaluated by conventional methods according to the standard RECIST 1.0 criteria: a complete response (CR) was defined as the disappearance of all measurable and evaluable evidence of disease; a partial response (PR) was defined as a > 30% decrease in the sum of the longest diameters of target lesions; stable disease (SD) was

ORGANISM(S): Homo sapiens

SUBMITTER: Sonia Molina-Pinelo 

PROVIDER: E-GEOD-48664 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress