ASC deficiency suppresses proliferation and prevents medulloblastoma incidence

ABSTRACT: Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is silenced by promoter methylation in many types of tumors, yet ASC’s role in most cancers remains unknown. Here, we show that ASC is highly expressed in a model of medulloblastoma, the most common malignant pediatric brain cancer. Importantly, while ASC deficiency did not affect normal cerebellar development, ASC knock-out mice in the Smoothened (ND2:SmoA1) transgenic model of medulloblastoma exhibited a profound reduction in medulloblastoma incidence and delayed tumor onset. Premalignant lesions in cerebella of ASC-/-;ND2:SmoA1 mice displayed a striking decrease in number of ectopic progenitors. While proliferation rates decreased with ASC deletion, apoptosis and differentiation markers remained un

ORGANISM(S): Mus musculus

SUBMITTER: Mohanish Deshmukh 

PROVIDER: E-GEOD-48682 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress