Global DNA methylation alterations reveal multiple pathways in the initiation and progression of colorectal cancer

ABSTRACT: Genetic and epigenetic alterations are a fundamental aspect of colorectal cancer formation. There is considerable heterogeneity between colorectal cancers regarding the mutations and methylated genes they carry, and this heterogeneity may arise early in the polyp-cancer sequence. However, our understanding of the epigenetic alterations and gene mutations in colon adenomas and their relation to colorectal cancer is incomplete. Thus, we have assessed the methylome in normal colon mucosa, tubular adenomas, and colorectal adenocarcinomas and have determined the relationship of these findings between adenomas and cancer in the colon. Genome-wide alterations in DNA methylation were found in the normal colon mucosa adjacent to colorectal cancer, tubular adenomas, and colorectal cancer. Three

ORGANISM(S): Homo sapiens

SUBMITTER: Yanxin Luo 

PROVIDER: E-GEOD-48684 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress