Morphological, genomic, and transcriptomic characterization of heterogeneity in chordoma cells

ABSTRACT: The classical sacrococcygeal chordoma tumor presents with a typical morphology of lobulated myxoid tumor tissue with cords, strands and nests of tumor cells consisting of small non-vacuolated cells, intermediate cells with a wide range of vacuolization and large heavily vacuolated (physaliferous) cells. Because of its rare incidence, lack of suited model systems and technical limitations analysis was only performed on bulk tumor mass neglecting its heterogeneous composition. We aimed at elucidating the differences between small non-vacuolated and large physaliferous cells on the genomic and transcriptomic level. Secondly, we intended to clarify whether the observed cell types are derived from genetically distinct clones or rather represent different phenotypes. Using the chordoma cell li

ORGANISM(S): Homo sapiens

SUBMITTER: Karin Wagner 

PROVIDER: E-GEOD-48779 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress