Decoding the transcriptional program of epidermal cell morphogenesis

ABSTRACT: Developmental programs are implemented by regulatory interactions between Transcription Factors (TFs) and their target genes, which remain yet poorly understood. While recent studies have focused on regulatory cascades of TFs that govern early development, little is known on how these are selected and controlled the ultimate cellular effectors of terminal differentiation. We addressed this question during late Drosophila embryogenesis when the finely tuned expression of a TF, Ovo/Shavenbaby (Svb), triggers the morphological differentiation of epidermal trichomes. We used chromatin immunoprecipitation and microarray profiling to identify Svb downstream target genes and show that Svb directly regulates a large set of terminal effectors of trichome formation. Functional assays delineated 18 S

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Rebecca Spokony 

PROVIDER: E-GEOD-48791 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress