Murine Schistosoma-Induced Pulmonary Hypertension: Microarray Data

ABSTRACT: Rationale: Schistosomiasis is one of the most common causes of pulmonary arterial hypertension worldwide, but the pathogenic mechanism by which the host inflammatory response contributes to vascular remodeling is unknown. We sought to identify signaling pathways that play protective or pathogenic roles in experimental Schistosoma-induced pulmonary vascular disease by whole-lung transcriptome analysis. Methods: Wildtype mice were experimentally exposed to S. mansoni ova by intraperitoneal sensitization followed by tail vein augmentation, and the phenotype assessed by right ventricular catheterization and tissue histology, RNA and protein analysis. Whole-lung transcriptome analysis by microarray and RNA sequencing was performed, the latter analyzed using 2 bioinformatic methods. Functional t

ORGANISM(S): Mus musculus

SUBMITTER: Brian Graham 

PROVIDER: E-GEOD-48936 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress