Psychotropic drug-induced gene expression alterations in mouse striatum II

ABSTRACT: To identify the molecular mechanisms that may initiate therapeutic effects, whole-genome expression profiling (Illumina Mouse WG-6 microarrays) of drug-induced alterations in the mouse brain was undertaken, with a focus on the time-course (1, 2, 4 and 8h) of gene expression changes produced by eighteen major psychotropic drugs: antidepressants, antipsychotics, anxiolytics, psychostimulants and opioids. The resulting database is freely accessible at www.genes2mind.org. Bioinformatics approaches led to the identification of three main drug-responsive genomic networks and indicated neurobiological pathways that mediate the alterations in transcription. Each tested psychotropic drug was characterized by a unique gene network expression profile related to its neuropharmacological properties. Fu

ORGANISM(S): Mus musculus

SUBMITTER: Marcin Piechota 

PROVIDER: E-GEOD-48954 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress