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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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RNA-Seq of eye tissues from C57BL/6J background mice at 1.5 h and 9.0 h after light onset

ABSTRACT: We report RNA-Seq experiments of whole eye tissues from C57BL/6J background mice at 1.5 h and 9.0 h after light onset to better understand photoreceptor phagocytosis Examine ocular tissue from mice at different time points

ORGANISM(S): Mus musculus

SUBMITTER: Xiaodong Bai

PROVIDER: E-GEOD-48974 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Photoreceptor phagocytosis is mediated by phosphoinositide signaling.

Mustafi Debarshi D Kevany Brian M BM Genoud Christel C Bai Xiaodong X Palczewski Krzysztof K

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20130802 11

Circadian oscillations in peripheral tissues, such as the retinal compartment of the eye, are critical to anticipating changing metabolic demands. Circadian shedding of retinal photoreceptor cell discs with subsequent phagocytosis by the neighboring retinal pigmented epithelium (RPE) is essential for removal of toxic metabolites and lifelong survival of these postmitotic neurons. Defects in photoreceptor phagocytosis can lead to severe retinal pathology, but the biochemical mechanisms remain poo ...[more]

PMID: 23913857

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