Expression data from maternally inflamed and Dap12-mutant microglia at E17.5.

ABSTRACT: Microglia colonize the brain parenchyma at early stages of development and accumulate in specific regions where they actively participate in cell death, angiogenesis, neurogenesis and synapse elimination. A recurring feature of embryonic microglial distribution is their association with developing axon tracts which, together with in vitro data, supports the idea of a physiological role for microglia in neurite development. Yet the demonstration of this role of microglia is still lacking. Here, we have studied the consequences of microglial dysfunction on the formation of the corpus callosum, the largest connective structure in the mammalian brain, which shows consistent microglial accumulation during development. We studied two models of microglial dysfunction: the loss-of-function of DAP1

ORGANISM(S): Mus musculus

SUBMITTER: Wouter Beumer 

PROVIDER: E-GEOD-49079 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress