MicroRNAs Implicated in Dysregulation of Gene Expression Following Human Lung Transplantation

ABSTRACT: Lung transplantation remains the only viable treatment option for the majority of patients with advanced lung diseases. However, 5-year post-transplant survival rates remain low primarily secondary to chronic rejection. Novel insights from global gene expression profiles may provide molecular phenotypes and therapeutic targets to improve outcomes after lung transplantation. We compared whole-genome transcriptional expression profiled using the Affymetrix Human Exon Array in peripheral blood mononuclear cells (PBMCs) in lung transplant patients and normal individuals. 364 dysregulated genes in Caucasian lung transplant patients relative to normal individuals. Enriched Gene Ontology biological processes and pathways included defense response, immune response” and response to wounding”. We t

ORGANISM(S): Homo sapiens

SUBMITTER: Tong Zhou 

PROVIDER: E-GEOD-49081 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress