Escape from X chromosome inactivation occurs within topologically associated domains

ABSTRACT: The spatial proximity between regulatory elements and their target genes has a profound affect on gene expression. X Chromosome Inactivation (XCI) is an epigenetic process by which an entire chromosome is rendered, for the most part, transcriptionally silent. A few genes are known to escape XCI and the mechanism for this escape remains unclear. Here, using mouse trophectodermal stem cells, we address whether specific chromosomal interactions facilitate escape from XCI by bringing escape-specific regulatory elements in close proximity to gene promoters. Our results suggest a model where escape from XCI occurs within topologically associated domains. As such, escaping genes and the regulatory sequences required for their escape are likely located within close linear proximity to each other.

ORGANISM(S): Mus musculus

SUBMITTER: Joshua Mugford 

PROVIDER: E-GEOD-49111 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress