Protective Role of IL6 in Vascular Remodeling in Schistosoma-Pulmonary Hypertension
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ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Brian Graham
PROVIDER: E-GEOD-49116 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension.
Graham Brian B BB Chabon Jacob J Kumar Rahul R Kolosionek Ewa E Gebreab Liya L Debella Elias E Edwards Michael M Diener Katrina K Shade Ted T Bifeng Gao G Bandeira Angela A Butrous Ghazwan G Jones Kenneth K Geraci Mark M Tuder Rubin M RM
American journal of respiratory cell and molecular biology 20131201 6
Schistosomiasis is one of the most common causes of pulmonary arterial hypertension worldwide, but the pathogenic mechanism by which the host inflammatory response contributes to vascular remodeling is unknown. We sought to identify signaling pathways that play protective or pathogenic roles in experimental Schistosoma-induced pulmonary vascular disease via whole-lung transcriptome analysis. Wild-type mice were experimentally exposed to Schistosoma mansoni ova by intraperitoneal sensitization fo ...[more]
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